Ontology highlight
ABSTRACT:
SUBMITTER: Warnier M
PROVIDER: S-EPMC5946064 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Warnier Marine M Flaman Jean-Michel JM Chouabe Christophe C Wiel Clotilde C Gras Baptiste B Griveau Audrey A Blanc Elena E Foy Jean-Philippe JP Mathot Pauline P Saintigny Pierre P Van Coppenolle Fabien F Vindrieux David D Martin Nadine N Bernard David D
Aging cell 20180215 3
Oncogenic signals lead to premature senescence in normal human cells causing a proliferation arrest and the elimination of these defective cells by immune cells. Oncogene-induced senescence (OIS) prevents aberrant cell division and tumor initiation. In order to identify new regulators of OIS, we performed a loss-of-function genetic screen and identified that the loss of SCN9A allowed cells to escape from OIS. The expression of this sodium channel increased in senescent cells during OIS. This upr ...[more]