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PGA: post-GWAS analysis for disease gene identification.

ABSTRACT: Summary:Although the genome-wide association study (GWAS) is a powerful method to identify disease-associated variants, it does not directly address the biological mechanisms underlying such genetic association signals. Here, we present PGA, a Perl- and Java-based program for post-GWAS analysis that predicts likely disease genes given a list of GWAS-reported variants. Designed with a command line interface, PGA incorporates genomic and eQTL data in identifying disease gene candidates and uses gene network and ontology data to score them based upon the strength of their relationship to the disease in question. Availability and implementation:http://zdzlab.einstein.yu.edu/1/pga.html. Contact:zhengdong.zhang@einstein.yu.edu. Supplementary information:Supplementary data are available at Bioinformatics online.

SUBMITTER: Lin JR

PROVIDER: S-EPMC5946835 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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PGA: post-GWAS analysis for disease gene identification.

Lin Jhih-Rong JR Jaroslawicz Daniel D Cai Ying Y Zhang Quanwei Q Wang Zhen Z Zhang Zhengdong D ZD

Bioinformatics (Oxford, England) 20180501 10

<h4>Summary</h4>Although the genome-wide association study (GWAS) is a powerful method to identify disease-associated variants, it does not directly address the biological mechanisms underlying such genetic association signals. Here, we present PGA, a Perl- and Java-based program for post-GWAS analysis that predicts likely disease genes given a list of GWAS-reported variants. Designed with a command line interface, PGA incorporates genomic and eQTL data in identifying disease gene candidates and ...[more]

PMID: 29300829

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