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Transplanted human thymus slices induce and support T-cell development in mice after cryopreservation.


ABSTRACT: Nude mouse human thymus transplant model: Fresh or cryopreserved and thawed human thymus slices were transplanted subcutaneously into recipient nude mice. Nude mice subsequently produced mouse CD3+ CD4+ T-cells.

SUBMITTER: Ross S 

PROVIDER: S-EPMC5947170 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Transplanted human thymus slices induce and support T-cell development in mice after cryopreservation.

Ross Susan S   Cheung Melissa M   Lau Ching-In CI   Sebire Neil N   Burch Michael M   Kilbride Peter P   Fuller Barry B   Morris G John GJ   Davies E Graham EG   Crompton Tessa T  

European journal of immunology 20180201 4


Nude mouse human thymus transplant model: Fresh or cryopreserved and thawed human thymus slices were transplanted subcutaneously into recipient nude mice. Nude mice subsequently produced mouse CD3<sup>+</sup> CD4<sup>+</sup> T-cells. ...[more]

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