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Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice.

ABSTRACT: Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI).Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components tested at a single concentration (40 ?M). Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice. This was accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA suppressed ATI by inhibiting macrophage recruitment and downregulating pro-inflammatory cytokines.These results suggest that GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation.

SUBMITTER: Suk S 

PROVIDER: S-EPMC5947313 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice.

Suk Sujin S   Kwon Gyoo Taik GT   Lee Eunjung E   Jang Woo Jung WJ   Yang Hee H   Kim Jong Hun JH   Thimmegowda N R NR   Chung Min-Yu MY   Kwon Jung Yeon JY   Yang Seunghee S   Kim Jason K JK   Park Jung Han Yoon JHY   Lee Ki Won KW  

Molecular nutrition & food research 20170720 10

<h4>Scope</h4>Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI).<h4>Methods and results</h4>Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1  ...[more]

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