A mutation in the progesterone receptor predisposes to HEV infection in HIV-positive patients.

ABSTRACT:

Background and aims

Infection with Hepatitis E virus (HEV) can cause chronic liver disease in immunocompromised hosts. In transplant recipients, the use of certain immunosuppressants and food habits has been proposed as risk factors for HEV. In individuals infected with the human immunodeficiency virus (HIV), risk factors for HEV infection are less clear. We aimed to study the association between a mutation in the progesterone receptor (PR) named PROGINS and HEV-infected in HIV-positive individuals.

Methods

We evaluated the presence of the SNP PROGINS via KASP in serum samples of 64 HIV-positive individuals and 187 healthy controls. We performed ELISA tests to address the serum levels of IL-10 and IL-12, as well as T-cell stimulation assays in peripheral blood to address imm

SUBMITTER: Debes JD 

PROVIDER: S-EPMC5947588 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature