Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka S
PROVIDER: S-EPMC5947873 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Tanaka Shigeru S Pfleger Christian C Lai Jen-Feng JF Roan Florence F Sun Shao-Cong SC Ziegler Steven F SF
Cell reports 20180401 3
Regulatory T cells (Tregs) are indispensable for the establishment of tolerance of self-antigens in animals. The transcriptional regulator Foxp3 is critical for Treg development and function, controlling the expression of genes important for Tregs through interactions with binding partners. We previously reported KAP1 as a binding partner of FOXP3 in human Tregs, but the mechanisms by which KAP1 affects Treg function were unclear. In this study, we analyzed mice with Treg-specific deletion of KA ...[more]