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Emerging Cellular Therapies for Glioblastoma Multiforme.

ABSTRACT: Glioblastoma multiforme (GBM) is the most common type of malignant primary brain cancer in adults. It is composed of highly malignant cells that display metastatic and angiogenic characteristics, making it resistant to current first-line chemotherapy with temozolomide, an alkylating agent. Despite many years of research, GBM remains poorly responsive to multiple available therapies, giving GBM patients, who receive the conventional combination of chemoradiotherapies and surgical resection, a dismal prognosis. There is growing evidence that the conventional systemic chemotherapeutic agents for GBM are ineffective in improving the disease progression. We aim to explore the emerging cellular therapies which may play a significant role in treating GBM.

SUBMITTER: Choi PJ

PROVIDER: S-EPMC5947919 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Emerging Cellular Therapies for Glioblastoma Multiforme.

Choi Paul J PJ Tubbs R Shane RS Oskouian Rod J RJ

Cureus 20180311 3

Glioblastoma multiforme (GBM) is the most common type of malignant primary brain cancer in adults. It is composed of highly malignant cells that display metastatic and angiogenic characteristics, making it resistant to current first-line chemotherapy with temozolomide, an alkylating agent. Despite many years of research, GBM remains poorly responsive to multiple available therapies, giving GBM patients, who receive the conventional combination of chemoradiotherapies and surgical resection, a dis ...[more]

PMID: 29755901

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