Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC5947947 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Wang Xiuxing X Prager Briana C BC Wu Qiulian Q Kim Leo J Y LJY Gimple Ryan C RC Shi Yu Y Yang Kailin K Morton Andrew R AR Zhou Wenchao W Zhu Zhe Z Obara Elisabeth Anne Adanma EAA Miller Tyler E TE Song Anne A Lai Sisi S Hubert Christopher G CG Jin Xun X Huang Zhi Z Fang Xiaoguang X Dixit Deobrat D Tao Weiwei W Zhai Kui K Chen Cong C Dong Zhen Z Zhang Guoxin G Dombrowski Stephen M SM Hamerlik Petra P Mack Stephen C SC Bao Shideng S Rich Jeremy N JN
Cell stem cell 20180401 4
Glioblastoma is the most lethal primary brain tumor; however, the crosstalk between glioblastoma stem cells (GSCs) and their supportive niche is not well understood. Here, we interrogated reciprocal signaling between GSCs and their differentiated glioblastoma cell (DGC) progeny. We found that DGCs accelerated GSC tumor growth. DGCs preferentially expressed brain-derived neurotrophic factor (BDNF), whereas GSCs expressed the BDNF receptor NTRK2. Forced BDNF expression in DGCs augmented GSC tumor ...[more]