Ontology highlight
ABSTRACT:
SUBMITTER: Brockway M
PROVIDER: S-EPMC5948117 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Brockway Marina M Fossa Anthony A AA Mason Jay W JW
Clinical pharmacology and therapeutics 20171208 2
US Food and Drug Administration (FDA) investigators recently demonstrated in a crossover study that early (J-T<sub>peak</sub> c) and late (T<sub>peak</sub> -T<sub>end</sub> ) repolarization duration can differentiate selective potassium block with a high arrhythmia risk from multichannel block with lower risk in subjects receiving dofetilide, verapamil, quinidine, or ranolazine. The purpose of this study was to determine if the findings by the FDA using their published software algorithm could b ...[more]