Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC5948211 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Zhang Congqiang C Seow Vui Yin VY Chen Xixian X Too Heng-Phon HP
Nature communications 20180511 1
Optimization of metabolic pathways consisting of large number of genes is challenging. Multivariate modular methods (MMMs) are currently available solutions, in which reduced regulatory complexities are achieved by grouping multiple genes into modules. However, these methods work well for balancing the inter-modules but not intra-modules. In addition, application of MMMs to the 15-step heterologous route of astaxanthin biosynthesis has met with limited success. Here, we expand the solution space ...[more]