Ontology highlight
ABSTRACT:
SUBMITTER: Saleem-Batcha R
PROVIDER: S-EPMC5949001 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20180423 19
The reactions of enzymes and cofactors with gaseous molecules such as dioxygen (O<sub>2</sub>) are challenging to study and remain among the most contentious subjects in biochemistry. To date, it is largely enigmatic how enzymes control and fine-tune their reactions with O<sub>2</sub>, as exemplified by the ubiquitous flavin-dependent enzymes that commonly facilitate redox chemistry such as the oxygenation of organic substrates. Here we employ O<sub>2</sub>-pressurized X-ray crystallography and ...[more]