Ontology highlight
ABSTRACT:
SUBMITTER: Maezawa S
PROVIDER: S-EPMC5949012 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Maezawa So S Hasegawa Kazuteru K Yukawa Masashi M Kubo Naoki N Sakashita Akihiko A Alavattam Kris G KG Sin Ho-Su HS Kartashov Andrey V AV Sasaki Hiroyuki H Barski Artem A Namekawa Satoshi H SH
Proceedings of the National Academy of Sciences of the United States of America 20180423 19
Repressive H3K27me3 and active H3K4me2/3 together form bivalent chromatin domains, molecular hallmarks of developmental potential. In the male germline, these domains are thought to persist into sperm to establish totipotency in the next generation. However, it remains unknown how H3K27me3 is established on specific targets in the male germline. Here, we demonstrate that a germline-specific Polycomb protein, SCML2, binds to H3K4me2/3-rich hypomethylated promoters in undifferentiated spermatogoni ...[more]