Two-year cortical trajectories are abnormal in children and adolescents with prenatal alcohol exposure.

ABSTRACT:

Objectives

Cortical abnormalities in prenatal alcohol exposure (PAE) are known, including in gyrification (LGI), thickness (CT), volume (CV), and surface area (CS). This study provides longitudinal and developmental context to the PAE cortical development literature.

Experimental design

Included: 58 children with PAE and 52 controls, ages 6-17 at enrollment, from four Collaborative Initiative on FASD (CIFASD) sites. Participants underwent a formal evaluation of physical anomalies and dysmorphic facial features associated with PAE. MRI data were collected on three platforms (Siemens, GE, and Philips) at four sites. Scans were spaced two years apart. Change in LGI, CT, CS, and CV were examined.

Principal observations

Several significant regional age-by-diagnosis linear

SUBMITTER: Hendrickson TJ 

PROVIDER: S-EPMC5949095 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature