The hydrophobic trap-the Achilles heel of RND efflux pumps.
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ABSTRACT:
SUBMITTER: Aron Z
PROVIDER: S-EPMC5949246 | biostudies-literature | 2018 Sep - Oct
REPOSITORIES: biostudies-literature
Publications
The hydrophobic trap-the Achilles heel of RND efflux pumps.
Aron Zachary Z Opperman Timothy J TJ
Research in microbiology 20171113 7-8
Resistance-nodulation-division (RND) superfamily efflux pumps play a major role in multidrug resistance (MDR) of Gram-negative pathogens by extruding diverse classes of antibiotics from the cell. There has been considerable interest in developing efflux pump inhibitors (EPIs) of RND pumps as adjunctive therapies. The primary challenge in EPI discovery has been the highly hydrophobic, poly-specific substrate binding site of the target. Recent findings have identified the hydrophobic trap, a narro ...[more]
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