Ontology highlight
ABSTRACT: Objective
As part of research on the heart-brain axis, we investigated the association of N-terminal pro-brain natriuretic peptide (NT-proBNP) with brain structure and function in a community-based cohort of middle-aged adults from the Brain Magnetic Resonance Imaging sub-study of the Coronary Artery Risk Development in Young Adults (CARDIA) Study.Approach and results
In a cohort of 634 community-dwelling adults with a mean (range) age of 50.4 (46-52) years, we examined the cross-sectional association of NT-proBNP to total, gray (GM) and white matter (WM) volumes, abnormal WM load and WM integrity, and to cognitive function tests [the Digit Symbol Substitution Test (DSST), the Stroop test, and the Rey Auditory-Verbal Learning Test]. These associations were examined using linear regression models adjusted for demographic and cardiovascular risk factors and cardiac output. Higher NT-proBNP concentration was significantly associated with smaller GM volume (??=?-3.44; 95% CI?=?-5.32, -0.53; p?=?0.003), even after additionally adjusting for cardiac output (??=?-2.93; 95% CI?=?-5.32, -0.53; p?=?0.017). Higher NT-proBNP levels were also associated with lower DSST scores. NT-proBNP was not related to WM volume, WM integrity, or abnormal WM load.Conclusion
In this middle-aged cohort, subclinical levels of NT-proBNP were related to brain function and specifically to GM and not WM measures, extending similar findings in older cohorts. Further research is warranted into biomarkers of cardiac dysfunction as a target for early markers of a brain at risk.
SUBMITTER: Ferguson IT
PROVIDER: S-EPMC5949318 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Ferguson Ian T IT Elbejjani Martine M Sabayan Behnam B Jacobs David R DR Meirelles Osorio O Sanchez Otto A OA Tracy Russell R Bryan Nick N Launer Lenore J LJ
Frontiers in neurology 20180507
<h4>Objective</h4>As part of research on the heart-brain axis, we investigated the association of N-terminal pro-brain natriuretic peptide (NT-proBNP) with brain structure and function in a community-based cohort of middle-aged adults from the Brain Magnetic Resonance Imaging sub-study of the Coronary Artery Risk Development in Young Adults (CARDIA) Study.<h4>Approach and results</h4>In a cohort of 634 community-dwelling adults with a mean (range) age of 50.4 (46-52) years, we examined the cross ...[more]