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Management of therapeutic anticoagulation in patients with intracerebral haemorrhage and mechanical heart valves.


ABSTRACT: Aims:Evidence is lacking regarding acute anticoagulation management in patients after intracerebral haemorrhage (ICH) with implanted mechanical heart valves (MHVs). Our objective was to investigate anticoagulation reversal and resumption strategies by evaluating incidences of haemorrhagic and thromboembolic complications, thereby defining an optimal time-window when to restart therapeutic anticoagulation (TA) in patients with MHV and ICH. Methods and results:We pooled individual patient-data (n?=?2504) from a nationwide multicentre cohort-study (RETRACE, conducted at 22 German centres) and eventually identified MHV-patients (n?=?137) with anticoagulation-associated ICH for outcome analyses. The primary outcome consisted of major haemorrhagic complications analysed during hospital stay according to treatment exposure (restarted TA vs. no-TA). Secondary outcomes comprised thromboembolic complications, the composite outcome (haemorrhagic and thromboembolic complications), timing of TA, and mortality. Adjusted analyses involved propensity-score matching and multivariable cox-regressions to identify optimal timing of TA. In 66/137 (48%) of patients TA was restarted, being associated with increased haemorrhagic (TA?=?17/66 (26%) vs. no-TA?=?4/71 (6%); P?

SUBMITTER: Kuramatsu JB 

PROVIDER: S-EPMC5950928 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Management of therapeutic anticoagulation in patients with intracerebral haemorrhage and mechanical heart valves.

Kuramatsu Joji B JB   Sembill Jochen A JA   Gerner Stefan T ST   Sprügel Maximilian I MI   Hagen Manuel M   Roeder Sebastian S SS   Endres Matthias M   Haeusler Karl Georg KG   Sobesky Jan J   Schurig Johannes J   Zweynert Sarah S   Bauer Miriam M   Vajkoczy Peter P   Ringleb Peter A PA   Purrucker Jan J   Rizos Timolaos T   Volkmann Jens J   Müllges Wolfgang W   Kraft Peter P   Schubert Anna-Lena AL   Erbguth Frank F   Nueckel Martin M   Schellinger Peter D PD   Glahn Jörg J   Knappe Ulrich J UJ   Fink Gereon R GR   Dohmen Christian C   Stetefeld Henning H   Fisse Anna Lena AL   Minnerup Jens J   Hagemann Georg G   Rakers Florian F   Reichmann Heinz H   Schneider Hauke H   Wöpking Sigrid S   Ludolph Albert Christian AC   Stösser Sebastian S   Neugebauer Hermann H   Röther Joachim J   Michels Peter P   Schwarz Michael M   Reimann Gernot G   Bäzner Hansjörg H   Schwert Henning H   Claßen Joseph J   Michalski Dominik D   Grau Armin A   Palm Frederick F   Urbanek Christian C   Wöhrle Johannes C JC   Alshammari Fahid F   Horn Markus M   Bahner Dirk D   Witte Otto W OW   Günther Albrecht A   Hamann Gerhard F GF   Lücking Hannes H   Dörfler Arnd A   Achenbach Stephan S   Schwab Stefan S   Huttner Hagen B HB  

European heart journal 20180501 19


<h4>Aims</h4>Evidence is lacking regarding acute anticoagulation management in patients after intracerebral haemorrhage (ICH) with implanted mechanical heart valves (MHVs). Our objective was to investigate anticoagulation reversal and resumption strategies by evaluating incidences of haemorrhagic and thromboembolic complications, thereby defining an optimal time-window when to restart therapeutic anticoagulation (TA) in patients with MHV and ICH.<h4>Methods and results</h4>We pooled individual p  ...[more]

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