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Management of therapeutic anticoagulation in patients with intracerebral haemorrhage and mechanical heart valves.

ABSTRACT: Aims:Evidence is lacking regarding acute anticoagulation management in patients after intracerebral haemorrhage (ICH) with implanted mechanical heart valves (MHVs). Our objective was to investigate anticoagulation reversal and resumption strategies by evaluating incidences of haemorrhagic and thromboembolic complications, thereby defining an optimal time-window when to restart therapeutic anticoagulation (TA) in patients with MHV and ICH. Methods and results:We pooled individual patient-data (n?=?2504) from a nationwide multicentre cohort-study (RETRACE, conducted at 22 German centres) and eventually identified MHV-patients (n?=?137) with anticoagulation-associated ICH for outcome analyses. The primary outcome consisted of major haemorrhagic complications analysed during hospital stay according to treatment exposure (restarted TA vs. no-TA). Secondary outcomes comprised thromboembolic complications, the composite outcome (haemorrhagic and thromboembolic complications), timing of TA, and mortality. Adjusted analyses involved propensity-score matching and multivariable cox-regressions to identify optimal timing of TA. In 66/137 (48%) of patients TA was restarted, being associated with increased haemorrhagic (TA?=?17/66 (26%) vs. no-TA?=?4/71 (6%); P?

SUBMITTER: Kuramatsu JB

PROVIDER: S-EPMC5950928 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Management of therapeutic anticoagulation in patients with intracerebral haemorrhage and mechanical heart valves.

Kuramatsu Joji B JB Sembill Jochen A JA Gerner Stefan T ST Sprügel Maximilian I MI Hagen Manuel M Roeder Sebastian S SS Endres Matthias M Haeusler Karl Georg KG Sobesky Jan J Schurig Johannes J Zweynert Sarah S Bauer Miriam M Vajkoczy Peter P Ringleb Peter A PA Purrucker Jan J Rizos Timolaos T Volkmann Jens J Müllges Wolfgang W Kraft Peter P Schubert Anna-Lena AL Erbguth Frank F Nueckel Martin M Schellinger Peter D PD Glahn Jörg J Knappe Ulrich J UJ Fink Gereon R GR Dohmen Christian C Stetefeld Henning H Fisse Anna Lena AL Minnerup Jens J Hagemann Georg G Rakers Florian F Reichmann Heinz H Schneider Hauke H Wöpking Sigrid S Ludolph Albert Christian AC Stösser Sebastian S Neugebauer Hermann H Röther Joachim J Michels Peter P Schwarz Michael M Reimann Gernot G Bäzner Hansjörg H Schwert Henning H Claßen Joseph J Michalski Dominik D Grau Armin A Palm Frederick F Urbanek Christian C Wöhrle Johannes C JC Alshammari Fahid F Horn Markus M Bahner Dirk D Witte Otto W OW Günther Albrecht A Hamann Gerhard F GF Lücking Hannes H Dörfler Arnd A Achenbach Stephan S Schwab Stefan S Huttner Hagen B HB

European heart journal 20180501 19

<h4>Aims</h4>Evidence is lacking regarding acute anticoagulation management in patients after intracerebral haemorrhage (ICH) with implanted mechanical heart valves (MHVs). Our objective was to investigate anticoagulation reversal and resumption strategies by evaluating incidences of haemorrhagic and thromboembolic complications, thereby defining an optimal time-window when to restart therapeutic anticoagulation (TA) in patients with MHV and ICH.<h4>Methods and results</h4>We pooled individual p ...[more]

PMID: 29529259

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Project description:INTRODUCTION:Pregnancy in patients with mechanical heart valves (MHVs) is associated with high maternal complications and fetal complications.Anticoagulation treatments serve to decrease their venous clotting risk. Although some anticoagulation regimens have been used for patients during pregnancy with MHVs, no one is definitively superior among different regimens in recent studies. For a better understanding of the clinical treatment which anticoagulation regimen is more effective and safer during the pregnancy in patients with MHVs, a Bayesian network meta-analysis is necessary. METHODS AND ANALYSIS:This protocol has been reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. Related studies until April 2019 will be searched in the following databases: PubMed, Embase,SinoMed and the using the OVID interface to search for evidence-based medicine reviews. A clinical trial registry (www.ClinicalTrials.gov) was also searched for unpublished trials. Both experimental studies (randomised clinical trials) and observational studies (cohort studies, case-control studies and case series studies) will be included in this study. Quality assessment will be conducted using Cochrane Collaboration's tool or Newcastle-Ottawa Scale based on their study designs. The primary outcomes of interest will be the frequencies of serious maternal and fetal events. The additional outcomes of interest will be adverse maternal events, mode of delivery and adverse fetal events. Pairwise and network meta-analysis will be conducted using R (V.3.4.4, R Foundation for Statistical Computing, Vienna, Austria) and Stata (V.14, StataCorp). The ranking probabilities will be estimated at each possible rank for each anticoagulation regimen using the surface under the cumulative ranking curve. Statistical inconsistency assessment, subgroup analysis, sensitivity analysis and publication bias assessment will be performed. ETHICS AND DISSEMINATION:Either ethics approval or patient consent is not necessary, because this study will be based on literature. The results of this study will be published in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER:CRD42019130659.

Dataset Information

Management of therapeutic anticoagulation in patients with intracerebral haemorrhage and mechanical heart valves.

Publications

Management of therapeutic anticoagulation in patients with intracerebral haemorrhage and mechanical heart valves.

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