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Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-?4 allele carriers aged 45-75: Results from the ALFA study.

ABSTRACT: Cerebral white matter hyperintensities are believed the consequence of small vessel disease and are associated with risk and progression of Alzheimer's disease. The ?4 allele of the APOE gene is the major factor accountable for Alzheimer's disease heritability. However, the relationship between white matter hyperintensities and APOE genotype in healthy subjects remains controversial. We investigated the association between APOE-?4 and vascular risk factors with white matter hyperintensities, and explored their interactions, in a cohort of cognitively healthy adults (45-75 years). White matter hyperintensities were assessed with the Fazekas Scale from magnetic resonance images (575 participants: 74 APOE-?4 homozygotes, 220 heterozygotes and 281 noncarriers) and classified into normal (Fazekas?

SUBMITTER: Rojas S 

PROVIDER: S-EPMC5951016 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45-75: Results from the ALFA study.

Rojas Santiago S   Brugulat-Serrat Anna A   Bargalló Nuria N   Minguillón Carolina C   Tucholka Alan A   Falcon Carles C   Carvalho Andreia A   Morán Sebastian S   Esteller Manel M   Gramunt Nina N   Fauria Karine K   Camí Jordi J   Molinuevo José L JL   Gispert Juan D JD  

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20170511 2

Cerebral white matter hyperintensities are believed the consequence of small vessel disease and are associated with risk and progression of Alzheimer's disease. The ɛ4 allele of the APOE gene is the major factor accountable for Alzheimer's disease heritability. However, the relationship between white matter hyperintensities and APOE genotype in healthy subjects remains controversial. We investigated the association between APOE-ɛ4 and vascular risk factors with white matter hyperintensities, and  ...[more]

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