Ontology highlight
ABSTRACT:
SUBMITTER: Murray LW
PROVIDER: S-EPMC5951287 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Murray Lyle W LW Satti Iman I Meyerowitz Jodi J Jones Matthew M Willberg Christian B CB Ussher James E JE Goedhals Dominique D Hurst Jacob J Phillips Rodney E RE McShane Helen H Vuuren Cloete van CV Frater John J
The Journal of infectious diseases 20180501 11
<h4>Background</h4>Human immunodeficiency virus (HIV)-infected individuals have a higher risk of developing active tuberculosis (TB) than HIV-uninfected individuals, but the mechanisms underpinning this are unclear. We hypothesized that depletion of specific components of Mycobacterium tuberculosis (Mtb)-specific CD4+ and CD8+ T-cell responses contributed to this increased risk.<h4>Methods</h4>Mtb-specific T-cell responses in 147 HIV-infected and 44 HIV-uninfected control subjects in a TB-endemi ...[more]