Ontology highlight
ABSTRACT:
SUBMITTER: Loftus C
PROVIDER: S-EPMC5951604 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Nano letters 20180420 5
An emerging new paradigm is that immune cell activation is controlled by transient interactions between supramolecular assemblies of receptors and ligands. Current immunotherapy biologic pharmaceuticals that activate or desensitize NK cells are, however, individual molecules that do not replicate this nanoscale organization of proteins. Here, we use nanoscale graphene oxide (NGO) as a template to generate soluble nanoscale clusters of Natural Killer cell-activating antibodies. We control nanoclu ...[more]