Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC5951717 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Wang W W Cox B M BM Jia Y Y Le A A AA Cox C D CD Jung K M KM Hou B B Piomelli D D Gall C M CM Lynch Gary G
Molecular psychiatry 20171114 8
Episodic memory, a fundamental component of human cognition, is significantly impaired in autism. We believe we report the first evidence for this problem in the Fmr1-knockout (KO) mouse model of Fragile X syndrome and describe potentially treatable underlying causes. The hippocampus is critical for the formation and use of episodes, with semantic (cue identity) information relayed to the structure via the lateral perforant path (LPP). The unusual form of synaptic plasticity expressed by the LPP ...[more]