Ontology highlight
ABSTRACT:
SUBMITTER: Gaboardi AJ
PROVIDER: S-EPMC5951731 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Gaboardi Angela J AJ Kressler Jochen J Snow Teresa K TK Balog Edward M EM
Muscle & nerve 20180130 6
<h4>Introduction</h4>Because impaired excitation-contraction coupling and reduced sarcoplasmic reticulum (SR) Ca<sup>2+</sup> release may contribute to the age-associated decline in skeletal muscle strength, we investigated the effect of aging on regulation of the skeletal muscle isoform of the ryanodine receptor (RyR1) by physiological channel ligands.<h4>Methods</h4>[<sup>3</sup> H]Ryanodine binding to membranes from 8- and 26-month-old Fischer 344 extensor digitorum longus (EDL) and soleus mu ...[more]