Ontology highlight
ABSTRACT:
SUBMITTER: Vertesy A
PROVIDER: S-EPMC5951918 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Nature communications 20180514 1
In contrast to mouse, human female germ cells develop asynchronously. Germ cells transition to meiosis, erase genomic imprints, and reactivate the X chromosome. It is unknown if these events all appear asynchronously, and how they relate to each other. Here we combine exome sequencing of human fetal and maternal tissues with single-cell RNA-sequencing of five donors. We reconstruct full parental haplotypes and quantify changes in parental allele-specific expression, genome-wide. First we disting ...[more]