Immune Microenvironment in Glioblastoma Subtypes.
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ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC5951930 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Immune Microenvironment in Glioblastoma Subtypes.
Chen Zhihong Z Hambardzumyan Dolores D
Frontiers in immunology 20180508
Glioblastomas (GBMs) are the most common and aggressive primary brain tumors. Due to their malignant growth and invasion into the brain parenchyma coupled with resistance to therapy, GBMs are among the deadliest of all cancers. GBMs are highly heterogeneous at both the molecular and histological levels. Hallmark histological structures include pseudopalisading necrosis and microvascular proliferation. In addition to high levels of intratumoral heterogeneity, GBMs also exhibit high levels of inte ...[more]
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