Dataset Information

Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites.

ABSTRACT: BACKGROUND:Enteroendocrine cells are essential for the regulation of glucose metabolism, but it is unknown whether they are associated with clinical features of metabolic syndrome (MetS) and fasting plasma metabolites. OBJECTIVE:We aimed to identify fasting plasma metabolites that associate with duodenal L cell, K cell and delta cell densities in subjects with MetS with ranging levels of insulin resistance. RESEARCH DESIGN AND METHODS:In this cross-sectional study, we evaluated L, K and delta cell density in duodenal biopsies from treatment-naïve males with MetS using machine-learning methodology. RESULTS:We identified specific clinical biomarkers and plasma metabolites associated with L cell and delta cell density. L cell density was associated with increased plasma metabolite levels including symmetrical dimethylarginine, 3-aminoisobutyric acid, kynurenine and glycine. In turn, these L cell-linked fasting plasma metabolites correlated with clinical features of MetS. CONCLUSIONS:Our results indicate a link between duodenal L cells, plasma metabolites and clinical characteristics of MetS. We conclude that duodenal L cells associate with plasma metabolites that have been implicated in human glucose metabolism homeostasis. Disentangling the causal relation between L cells and these metabolites might help to improve the (small intestinal-driven) pathophysiology behind insulin resistance in human obesity.

SUBMITTER: van Baar ACG

PROVIDER: S-EPMC5952241 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites.

van Baar Annieke C G ACG Prodan Andrei A Wahlgren Camilla D CD Poulsen Steen S SS Knop Filip K FK Groen Albert K AK Bergman Jacques J JJ Nieuwdorp Max M Levin Evgeni E

Endocrine connections 20180418 5

<h4>Background</h4>Enteroendocrine cells are essential for the regulation of glucose metabolism, but it is unknown whether they are associated with clinical features of metabolic syndrome (MetS) and fasting plasma metabolites.<h4>Objective</h4>We aimed to identify fasting plasma metabolites that associate with duodenal L cell, K cell and delta cell densities in subjects with MetS with ranging levels of insulin resistance.<h4>Research design and methods</h4>In this cross-sectional study, we evalu ...[more]

PMID: 29669802

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Dataset Information

Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites.

Publications

Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites.

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