An enantioselective artificial Suzukiase based on the biotin-streptavidin technology.
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ABSTRACT:
SUBMITTER: Chatterjee A
PROVIDER: S-EPMC5953008 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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An enantioselective artificial Suzukiase based on the biotin-streptavidin technology.
Chatterjee Anamitra A Mallin Hendrik H Klehr Juliane J Vallapurackal Jaicy J Finke Aaron D AD Vera Laura L Marsh May M Ward Thomas R TR
Chemical science 20151019 1
Introduction of a biotinylated monophosphine palladium complex within streptavidin affords an enantioselective artificial Suzukiase. Site-directed mutagenesis allowed the optimization of the activity and the enantioselectivity of this artificial metalloenzyme. A variety of atropisomeric biaryls were produced in good yields and up to 90% ee. The hybrid catalyst described herein shows comparable TOF to the previous aqueous-asymmetric Suzuki catalysts, and excellent stability under the reaction con ...[more]
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