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The Wnt Signaling Pathway and Related Therapeutic Drugs in Autism Spectrum Disorder.

ABSTRACT: Autism spectrum disorder (ASD) is a series of neurodevelopmental disorder with a large genetic component. However, the pathogenic genes and molecular mechanisms of ASD have not been clearly defined. Recent technological advancements, such as next-generation sequencing, have led to the identification of certain loci that is responsible for the pathophysiology of ASD. Three functional pathways, such as chromatin remodeling, Wnt signaling and mitochondrial dysfunction are potentially involved in ASD. In this review, we will focus on recent studies of the involvement of Wnt signaling pathway components in ASD pathophysiology and related drugs used in ASD treatment.

SUBMITTER: Bae SM

PROVIDER: S-EPMC5953011 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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The Wnt Signaling Pathway and Related Therapeutic Drugs in Autism Spectrum Disorder.

Bae Seung Min SM Hong Ji Yeon JY

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 20180501 2

Autism spectrum disorder (ASD) is a series of neurodevelopmental disorder with a large genetic component. However, the pathogenic genes and molecular mechanisms of ASD have not been clearly defined. Recent technological advancements, such as next-generation sequencing, have led to the identification of certain loci that is responsible for the pathophysiology of ASD. Three functional pathways, such as chromatin remodeling, Wnt signaling and mitochondrial dysfunction are potentially involved in AS ...[more]

PMID: 29739125

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