Ontology highlight
ABSTRACT:
SUBMITTER: Bouchareychas L
PROVIDER: S-EPMC5954154 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Bouchareychas Laura L Grössinger Eva M EM Kang Mincheol M Adamopoulos Iannis E IE
Scientific reports 20180515 1
γδ T cells have been implicated in inflammatory diseases as an important link between the innate and adaptive immune responses, however, their role in inflammatory arthritis remain unclear. To define the contribution of γδ T cells in the pathogenesis of inflammatory arthritis, we performed gene transfer of IL-23 in B10.RIII mice to establish joint inflammation in the presence or absence of γδ T cells. We demonstrated that γδ T cell blockade has a protective effect on arthritis incidence and seve ...[more]