Voltage-dependent Ca2+ channels promote branching morphogenesis of salivary glands by patterning differential growth.
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ABSTRACT:
SUBMITTER: Kim JM
PROVIDER: S-EPMC5954160 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Voltage-dependent Ca<sup>2+</sup> channels promote branching morphogenesis of salivary glands by patterning differential growth.
Kim J M JM Choi S S Lee S W SW Park K K
Scientific reports 20180515 1
Branching morphogenesis is a crucial part of early developmental processes in diverse organs, but the detailed mechanism of this morphogenic event remains to be elucidated. Here we introduce an unknown mechanism leading to branching morphogenesis using mouse embryonic organotypic cultures with time-lapse live imaging. We found spatially expressed L-type voltage-dependent Ca<sup>2+</sup> channels (VDCCs) in the peripheral layers of developing epithelial buds and identified the VDCCs as a core sig ...[more]
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