Ontology highlight
ABSTRACT:
SUBMITTER: Beceiro S
PROVIDER: S-EPMC5954201 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Beceiro Susana S Pap Attila A Czimmerer Zsolt Z Sallam Tamer T Guillén Jose A JA Gallardo Germán G Hong Cynthia C A-Gonzalez Noelia N Tabraue Carlos C Diaz Mercedes M Lopez Felix F Matalonga Jonathan J Valledor Annabel F AF Dominguez Pilar P Ardavin Carlos C Delgado-Martin Cristina C Partida-Sanchez Santiago S Rodriguez-Fernandez Jose Luis JL Nagy Laszlo L Tontonoz Peter P Castrillo Antonio A
Molecular and cellular biology 20180430 10
The liver X receptors (LXRs) are ligand-activated nuclear receptors with established roles in the maintenance of lipid homeostasis in multiple tissues. LXRs exert additional biological functions as negative regulators of inflammation, particularly in macrophages. However, the transcriptional responses controlled by LXRs in other myeloid cells, such as dendritic cells (DCs), are still poorly understood. Here we used gain- and loss-of-function models to characterize the impact of LXR deficiency on ...[more]