Dataset Information
Myelin status is associated with change in functional mobility following slope walking in people with multiple sclerosis.
Ontology highlight
ABSTRACT: Background
The level of myelin disruption in multiple sclerosis patients may impact the capacity for training-induced neuroplasticity and the magnitude of therapeutic response to rehabilitation interventions. Downslope walking has been shown to increase functional mobility in individuals with multiple sclerosis, but it is unclear if myelin status influences therapeutic response.Objective
The current study aimed to examine the relationship between baseline myelin status and change in functional mobility after a walking intervention.Methods
The Timed Up and Go test was used to measure functional mobility before and after completion of a repeated, six-session slope walking intervention in 16 participants with relapsing-remitting multiple sclerosis. Multi-component T2 relaxation imaging was used to index myelin water fraction of overall water content in brain tissue compartments.Results
Results demonstrated that the ratio of the myelin water fraction in lesion to normal-appearing white matter (myelin water fraction ratio) significantly predicted 31% of the variance in change in Timed Up and Go score after the downslope walking intervention, where less myelin disruption was associated with greater intervention response.Conclusions
Myelin water content fraction ratio may offer a neural biomarker of myelin to identify potential responders to interventions targeting functional impairments in multiple sclerosis.
SUBMITTER: King EM
PROVIDER: S-EPMC5954324 | biostudies-literature | 2018 Apr-Jun
REPOSITORIES: biostudies-literature
Publications
Myelin status is associated with change in functional mobility following slope walking in people with multiple sclerosis.
Multiple sclerosis journal - experimental, translational and clinical 20180427 2
<h4>Background</h4>The level of myelin disruption in multiple sclerosis patients may impact the capacity for training-induced neuroplasticity and the magnitude of therapeutic response to rehabilitation interventions. Downslope walking has been shown to increase functional mobility in individuals with multiple sclerosis, but it is unclear if myelin status influences therapeutic response.<h4>Objective</h4>The current study aimed to examine the relationship between baseline myelin status and change ...[more]