Ontology highlight
ABSTRACT:
SUBMITTER: Bonomi M
PROVIDER: S-EPMC5954442 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Bonomi Massimiliano M Pellarin Riccardo R Vendruscolo Michele M
Biophysical journal 20180401 7
Cryo-electron microscopy is rapidly emerging as a powerful technique to determine the structures of complex macromolecular systems elusive to other techniques. Because many of these systems are highly dynamical, characterizing their movements is also a crucial step to unravel their biological functions. To achieve this goal, we report an integrative modeling approach to simultaneously determine structure and dynamics of macromolecular systems from cryo-electron microscopy density maps. By quanti ...[more]