Unknown

Dataset Information

0

The ligand unwrapping/rewrapping pathway that exchanges metals in S-acetylated, hexacoordinate N2S2O2 complexes.


ABSTRACT: The effect of S-acetylation in MN2S2 complexes on metal exchange reactivity was examined in a series of MN2S2O2 complexes. While clean exchange processes do not occur for the MN2S2 derivatives where formation of S-bridged aggregates predominate, acetylation permits the metal exchange with hierarchy that follows the Irving-Williams series of stability for first row transition metals: Fe2+ < Co2+ < Ni2+ < Cu2+ > Zn2+. The rate determining step consistent with kinetic parameters depends on both M and M', supporting a mechanism of exchange that involves ligand unwrapping/rewrapping process as earlier defined by Margerum et al. for M(EDTA) systems. The enhanced metal exchange deriving from S-acetylation is of significance to probes and detection of cysteine-S metallo-proteins and metallo-enzyme active sites, and highlights a new role for S-acetylation.

SUBMITTER: Denny JA 

PROVIDER: S-EPMC5954489 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

The ligand unwrapping/rewrapping pathway that exchanges metals in <i>S</i>-acetylated, hexacoordinate N<sub>2</sub>S<sub>2</sub>O<sub>2</sub> complexes.

Denny J A JA   Foley W S WS   Todd A D AD   Darensbourg M Y MY  

Chemical science 20150907 12


The effect of <i>S</i>-acetylation in MN<sub>2</sub>S<sub>2</sub> complexes on metal exchange reactivity was examined in a series of MN<sub>2</sub>S<sub>2</sub>O<sub>2</sub> complexes. While clean exchange processes do not occur for the MN<sub>2</sub>S<sub>2</sub> derivatives where formation of <i>S</i>-bridged aggregates predominate, acetylation permits the metal exchange with hierarchy that follows the Irving-Williams series of stability for first row transition metals: Fe<sup>2+</sup> < Co<su  ...[more]

Similar Datasets

| S-EPMC9920543 | biostudies-literature
| S-EPMC9965685 | biostudies-literature
| S-EPMC9417100 | biostudies-literature
| S-EPMC10618332 | biostudies-literature
| S-EPMC10430601 | biostudies-literature
| S-EPMC8612373 | biostudies-literature
| S-EPMC7589404 | biostudies-literature
2010-10-08 | E-GEOD-1573 | biostudies-arrayexpress
| S-EPMC9419620 | biostudies-literature
| S-EPMC4886218 | biostudies-literature