Ontology highlight
ABSTRACT:
SUBMITTER: Kumari R
PROVIDER: S-EPMC5955097 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Kumari Rashmi R Silic Martin R MR Jones-Hall Yava L YL Nin-Velez Alexandra A Yang Jer-Yen JY Mittal Suresh K SK Zhang GuangJun G
Oncotarget 20180504 34
Malignant peripheral nerve sheath tumors (MPNSTs) are a type of sarcoma with poor prognosis due to their complex genetic changes, invasive growth, and insensitivity to chemo- and radiotherapies. One of the most frequently lost chromosome arms in human MPNSTs is chromosome 9p. However, the cancer driver genes located on it remain largely unknown, except the tumor suppressor gene, p16 <i>(INK4)/CDKN2A</i>. Previously, we identified <i>RECK</i> as a tumor suppressor gene candidate on chromosome 9p ...[more]