Ontology highlight
ABSTRACT:
SUBMITTER: Miyaoka Y
PROVIDER: S-EPMC5955755 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Miyaoka Yuta Y Jin Denan D Tashiro Keitaro K Masubuchi Shinsuke S Ozeki Maiko M Hirokawa Fumitoshi F Hayashi Michihiro M Takai Shinji S Uchiyama Kazuhisa K
Experimental animals 20180101 2
Nonalcoholic steatohepatitis (NASH), in which there is steatosis and fibrosis in the liver, is linked to metabolic syndrome and progresses to hepatic cirrhosis. In this study, a novel hamster NASH model derived from metabolic syndrome was made using hamsters. Hamsters were fed a normal or a high-fat and high-cholesterol (HFC) diet for 12 weeks. Body weight and the ratio of liver weight to body weight were significantly greater in HFC diet-fed hamsters than in normal diet-fed hamsters. Triglyceri ...[more]