How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations.
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ABSTRACT:
SUBMITTER: Rehrauer H
PROVIDER: S-EPMC5955862 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations.
Rehrauer Hubert H Wu Licun L Blum Walter W Pecze Lazslo L Henzi Thomas T Serre-Beinier Véronique V Aquino Catherine C Vrugt Bart B de Perrot Marc M Schwaller Beat B Felley-Bosco Emanuela E
Oncogene 20180306 20
Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mesothelium with further activation in tumors, paralleled by increased levels of cells with nuclear YAP/TAZ. Arg1 was one of the highest upregulated genes in inflamed tissue and tumor. Inflamed tissue sh ...[more]
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