Discovery of a novel IL-15 based protein with improved developability and efficacy for cancer immunotherapy.
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ABSTRACT:
SUBMITTER: Hu Q
PROVIDER: S-EPMC5955975 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
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Discovery of a novel IL-15 based protein with improved developability and efficacy for cancer immunotherapy.
Hu Qiyue Q Ye Xin X Qu Xiangdong X Cui Dongbing D Zhang Lei L Xu Zhibin Z Wan Hong H Zhang Lianshan L Tao Weikang W
Scientific reports 20180516 1
Interleukin-15 (IL-15) can promote both innate and adaptive immune reactions by stimulating CD8<sup>+</sup>/CD4<sup>+</sup> T cells and natural killer cells (NK) while showing no effect in activating T-regulatory (Treg) cells or inducing activation-associated death among effector T cells and NK cells. Thus, IL-15 is considered as one of the most promising molecules for antitumor immune therapy. To improve the drug-like properties of natural IL-15, we create an IL-15-based molecule, named P22339, ...[more]
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