Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.
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ABSTRACT:
SUBMITTER: Ramirez J
PROVIDER: S-EPMC5955978 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
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Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.
Ramírez Julia J Duijvenboden Stefan van SV Ntalla Ioanna I Mifsud Borbala B Warren Helen R HR Tzanis Evan E Orini Michele M Tinker Andrew A Lambiase Pier D PD Munroe Patricia B PB
Nature communications 20180516 1
Impaired capacity to increase heart rate (HR) during exercise (ΔHR<sup>ex</sup>), and a reduced rate of recovery post-exercise (ΔHR<sup>rec</sup>) are associated with higher cardiovascular mortality rates. Currently, the genetic basis of both phenotypes remains to be elucidated. We conduct genome-wide association studies (GWASs) for ΔHR<sup>ex</sup> and ΔHR<sup>rec</sup> in ~40,000 individuals, followed by replication in ~27,000 independent samples, all from UK Biobank. Six and seven single-nucl ...[more]
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