Ontology highlight
ABSTRACT:
SUBMITTER: Piddock RE
PROVIDER: S-EPMC5956761 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Piddock Rachel E RE Marlein Christopher R CR Abdul-Aziz Amina A Shafat Manar S MS Auger Martin J MJ Bowles Kristian M KM Rushworth Stuart A SA
Journal of hematology & oncology 20180516 1
Multiple myeloma (MM) remains an incurable malignancy despite the recent advancements in its treatment. The protective effects of the niche in which it develops has been well documented; however, little has been done to investigate the MM cell's ability to 're-program' cells within its environment to benefit disease progression. Here, we show that MM-derived macrophage migratory inhibitory factor (MIF) stimulates bone marrow stromal cells to produce the disease critical cytokines IL-6 and IL-8, ...[more]