Ontology highlight
ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC5956890 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Yu Jinha J Ahn Seyeon S Kim Hee Jin HJ Lee Moonyoung M Ahn Sungjin S Kim Jungmin J Jin Sun Hee SH Lee Eunyoung E Kim Gyudong G Cheong Jae Hoon JH Jacobson Kenneth A KA Jeong Lak Shin LS Noh Minsoo M
Journal of medicinal chemistry 20170828 17
A<sub>3</sub> adenosine receptor (AR) ligands including A<sub>3</sub> AR agonist, N<sup>6</sup>-(3-iodobenzyl)adenosine-5'-N-methyluronamide (1a, IB-MECA) were examined for adiponectin production in human bone marrow mesenchymal stem cells (hBM-MSCs). In this model, 1a significantly increased adiponectin production, which is associated with improved insulin sensitivity. However, A<sub>3</sub> AR antagonists also promoted adiponectin production in hBM-MSCs, indicating that the A<sub>3</sub> AR pa ...[more]