Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC5957072 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Chen Liang L Chen Jia-Yu JY Huang Yi-Jou YJ Gu Ying Y Qiu Jinsong J Qian Hao H Shao Changwei C Zhang Xuan X Hu Jing J Li Hairi H He Shunmin S Zhou Yu Y Abdel-Wahab Omar O Zhang Dong-Er DE Fu Xiang-Dong XD
Molecular cell 20180127 3
Mutations in several general pre-mRNA splicing factors have been linked to myelodysplastic syndromes (MDSs) and solid tumors. These mutations have generally been assumed to cause disease by the resultant splicing defects, but different mutations appear to induce distinct splicing defects, raising the possibility that an alternative common mechanism is involved. Here we report a chain of events triggered by multiple splicing factor mutations, especially high-risk alleles in SRSF2 and U2AF1, inclu ...[more]