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ABSTRACT: Purpose
To identify a clinically meaningful cut-point for the single item dry mouth question of the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN).Methods
Head and neck cancer survivors who had received radiation therapy (RT) completed the MDASI-HN, the University of Michigan Hospital Xerostomia Questionnaire (XQ), and the health visual analog scale (VAS) of the EuroQol Five Dimension Questionnaire (EQ-5D). The Bayesian information criteria (BIC) were used to test the prediction power of each tool for EQ-5D VAS. The modified Breiman recursive partitioning analysis (RPA) was used to identify a cut point of the MDASI-HN dry mouth score (MDASI-HN-DM) with EQ-5D VAS, using a ROC-based approach; regression analysis was used to confirm the threshold effect size.Results
Two-hundred seven respondents formed the cohort. Median follow-up from the end of RT to questionnaire completion was 88 months. The single item MDASI-HN-DM score showed a linear relationship with the XQ composite score (ρ = 0.80, p < 0.001). The MDASI-HN-DM displayed improved model performance for association with EQ-5D VAS as compared to XQ (BIC of 1803.7 vs. 2016.9, respectively). RPA showed that an MDASI-HN-DM score of ≥6 correlated with EQ-5D VAS decline (LogWorth 5.5).Conclusion
The single item MDASI-HN-DM correlated with the multi-item XQ and performed favorably in the prediction of QOL. A MDASI-HN-DM cut point of ≥6 correlated with decline in QOL.
SUBMITTER: MD Anderson Head and Neck Cancer Symptom Working Group
PROVIDER: S-EPMC5957088 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Kamal Mona M Rosenthal David I DI Volpe Stefania S Goepfert Ryan P RP Garden Adam S AS Hutcheson Katherine A KA Al Feghali Karine A KA Meheissen Mohamed Ahmed Mohamed MAM Eraj Salman A SA Dursteler Amy E AE Williams Bowman B Smith Joshua B JB Aymard Jeremy M JM Berends Joel J White Aubrey L AL Frank Steven J SJ Morrison William H WH Cardoso Richard R Chambers Mark S MS Sturgis Erich M EM Mendoza Tito R TR Lu Charles C Mohamed Abdallah S R ASR Fuller Clifton D CD Gunn G Brandon GB
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20171208 1
<h4>Purpose</h4>To identify a clinically meaningful cut-point for the single item dry mouth question of the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN).<h4>Methods</h4>Head and neck cancer survivors who had received radiation therapy (RT) completed the MDASI-HN, the University of Michigan Hospital Xerostomia Questionnaire (XQ), and the health visual analog scale (VAS) of the EuroQol Five Dimension Questionnaire (EQ-5D). The Bayesian information criteria (BIC) were used to test ...[more]