Ontology highlight
ABSTRACT:
SUBMITTER: Mayer CT
PROVIDER: S-EPMC5957278 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20170921 6360
B cells undergo rapid cell division and affinity maturation in anatomically distinct sites in lymphoid organs called germinal centers (GCs). Homeostasis is maintained in part by B cell apoptosis. However, the precise contribution of apoptosis to GC biology and selection is not well defined. We developed apoptosis-indicator mice and used them to visualize, purify, and characterize dying GC B cells. Apoptosis is prevalent in the GC, with up to half of all GC B cells dying every 6 hours. Moreover, ...[more]