Ontology highlight
ABSTRACT:
SUBMITTER: Marek R
PROVIDER: S-EPMC5957529 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nature neuroscience 20180205 3
The medial prefrontal cortex (mPFC) has been implicated in the extinction of emotional memories, including conditioned fear. We found that ventral hippocampal (vHPC) projections to the infralimbic (IL) cortex recruited parvalbumin-expressing interneurons to counter the expression of extinguished fear and promote fear relapse. Whole-cell recordings ex vivo revealed that optogenetic activation of vHPC input to amygdala-projecting pyramidal neurons in the IL was dominated by feed-forward inhibition ...[more]