Ontology highlight
ABSTRACT:
SUBMITTER: Valle-Orero J
PROVIDER: S-EPMC5957541 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
The journal of physical chemistry letters 20170725 15
Protein aging may manifest as a mechanical disease that compromises tissue elasticity. As proved recently, while proteins respond to changes in force with an instantaneous elastic recoil followed by a folding contraction, aged proteins break bad, becoming unstructured polymers. Here, we explain this phenomenon in the context of a free energy model, predicting the changes in the folding landscape of proteins upon oxidative aging. Our findings validate that protein folding under force is constitut ...[more]