Genome-wide haplotype association analysis of primary biliary cholangitis risk in Japanese.
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ABSTRACT:
SUBMITTER: Im C
PROVIDER: S-EPMC5958065 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Genome-wide haplotype association analysis of primary biliary cholangitis risk in Japanese.
Im Cindy C Sapkota Yadav Y Moon Wonjong W Kawashima Minae M Nakamura Minoru M Tokunaga Katsushi K Yasui Yutaka Y
Scientific reports 20180517 1
Primary biliary cholangitis (PBC) susceptibility loci have largely been discovered through single SNP association testing. In this study, we report genic haplotype patterns associated with PBC risk genome-wide in two Japanese cohorts. Among the 74 genic PBC risk haplotype candidates we detected with a novel methodological approach in a discovery cohort of 1,937 Japanese, nearly two-thirds were replicated (49 haplotypes, Bonferroni-corrected P < 6.8 × 10<sup>-4</sup>) in an independent Japanese c ...[more]
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