Ontology highlight
ABSTRACT:
SUBMITTER: Siegemund M
PROVIDER: S-EPMC5958125 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Siegemund Martin M Schneider Felix F Hutt Meike M Seifert Oliver O Müller Ines I Kulms Dagmar D Pfizenmaier Klaus K Kontermann Roland E RE
Scientific reports 20180517 1
Single-chain formats of TNF-related apoptosis inducing ligand (scTRAIL) can serve as effector components of tumour-associated antigen-targeted as well as non-targeted fusion proteins, being characterized by high tumour cell-specific induction of apoptosis through death receptor activation. We studied the suitability of immunoglobulin G as a scaffold for oligovalent and bispecific TRAIL fusion proteins. Thus, we developed novel targeted hexa- and dodecavalent IgG-scTRAIL molecules by fusing scTRA ...[more]