Ontology highlight
ABSTRACT:
SUBMITTER: Zatolochnaya OV
PROVIDER: S-EPMC5958347 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Chemical science 20180423 19
A new class of tunable heterophosphole dimeric ligands have been designed and synthesized. These ligands have enabled the first examples of Cu-catalyzed hydrogenation of 2-substituted-1-tetralones and related heteroaryl ketones <i>via</i> dynamic kinetic resolution, simultaneously creating two contiguous stereogenic centers with up to >99 : 1 dr and 98 : 2 er. The ligand-Cu complexes were isolated and characterized by single crystal X-ray, and DFT calculations revealed a novel heteroligated dime ...[more]