Effects of insulin and analogues on carcinogen-induced mammary tumours in high-fat-fed rats.
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ABSTRACT:
SUBMITTER: Mori Y
PROVIDER: S-EPMC5958747 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Effects of insulin and analogues on carcinogen-induced mammary tumours in high-fat-fed rats.
Mori Yusaku Y Ko Eunhyoung E Furrer Rudolf R Qu Linda C LC Wiber Stuart C SC Fantus I George IG Thevis Mario M Medline Alan A Giacca Adria A
Endocrine connections 20180424 5
It is not fully clarified whether insulin glargine, an analogue with a high affinity for insulin-like growth factor-1 receptor (IGF-1R), increases the risk for cancers that abundantly express IGF-1R such as breast cancer or some types of breast cancer. To gain insight into this issue, female Sprague-Dawley rats fed a high-fat diet were given the carcinogen N-methyl-N-nitrosourea and randomly assigned to vehicle (control), NPH (unmodified human insulin), glargine or detemir (<i>n</i> = 30 per tre ...[more]
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Project description:S-soluble phase
2010-12-03 | PRD000818 | Pride