Ontology highlight
ABSTRACT:
SUBMITTER: Lee JV
PROVIDER: S-EPMC5959234 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Lee Joyce V JV Berry Corbett T CT Kim Karla K Sen Payel P Kim Taehyong T Carrer Alessandro A Trefely Sophie S Zhao Steven S Fernandez Sully S Barney Lauren E LE Schwartz Alyssa D AD Peyton Shelly R SR Snyder Nathaniel W NW Berger Shelley L SL Freedman Bruce D BD Wellen Kathryn E KE
Genes & development 20180419 7-8
The metabolite acetyl-coenzyme A (acetyl-CoA) is the required acetyl donor for lysine acetylation and thereby links metabolism, signaling, and epigenetics. Nutrient availability alters acetyl-CoA levels in cancer cells, correlating with changes in global histone acetylation and gene expression. However, the specific molecular mechanisms through which acetyl-CoA production impacts gene expression and its functional roles in promoting malignant phenotypes are poorly understood. Here, using histone ...[more]