Ontology highlight
ABSTRACT:
SUBMITTER: Jiao L
PROVIDER: S-EPMC5959330 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Jiao Lin L Zhang Hai-Liang HL Li Dan-Dan DD Yang Ke-Li KL Tang Jun J Li Xuan X Ji Jiao J Yu Yan Y Wu Rui-Yan RY Ravichandran Senthilkumar S Liu Jian-Jun JJ Feng Gong-Kan GK Chen Min-Shan MS Zeng Yi-Xin YX Deng Rong R Zhu Xiao-Feng XF
Autophagy 20171217 4
Impaired macroautophagy/autophagy and high levels of glycolysis are prevalent in liver cancer. However, it remains unknown whether there is a regulatory relationship between autophagy and glycolytic metabolism. In this study, by utilizing cancer cells with basal or impaired autophagic flux, we demonstrated that glycolytic activity is negatively correlated with autophagy level. The autophagic degradation of HK2 (hexokinase 2), a crucial glycolytic enzyme catalyzing the conversion of glucose to gl ...[more]